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Article

Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.

Biological chemistry - 1 Sept 2016

Burgener Sabrina S, Baumann Mathias, Basilico Paola, Remold-O'Donnell Eileen, Touw Ivo P, Benarafa Charaf

Abstract excerpt

Serpinb1 is an inhibitor of neutrophil granule serine proteases cathepsin G, proteinase-3 and elastase. One of its core physiological functions is to protect neutrophils from granule protease-mediated cell death. Mice lacking Serpinb1a (Sb1a-/-), its mouse ortholog, have reduced bone marrow neutrophil numbers due to cell death mediated by cathepsin G and the mice show increased susceptibility to lung infections....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27107834
DOI: 10.1515/hsz-2016-0132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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