Article
Increased neutrophil respiratory burst in bcr-null mutants.
Cell - 10 Mar 1995
Voncken J W, van Schaick H, Kaartinen V, Deemer K, Coates T, Landing B, Pattengale P, Dorseuil O, Bokoch G M, Groffen J
Abstract excerpt
Philadelphia (Ph)-positive leukemias invariably contain a chromosomal translocation fusing BCR to ABL. The BCR-ABL protein is responsible for leukemogenesis. Here we show that exposure of bcr-null mutant mice to gram-negative endotoxin led to severe septic shock and increased tissue injury by neu...
Topics
- Actin Cytoskeleton
- Animals
- Endotoxins
- Female
- GTP-Binding Proteins
- Gene Targeting
- Lipopolysaccharides
- Male
- Mice
- Mice, Inbred C57BL
- Mutation
- Neutropenia
- Neutrophil Activation
- Neutrophils
- Oncogene Proteins
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcr