Article

Rac2 Hyperactivity Drives Neutrophil Degranulation, Myeloperoxidase Deficiency, and Lymphopenia

2026-05-15

Abstract excerpt

Patients with a dominant mutation in the Rho GTPase RAC2, RAC2 E62K , which hyperactivates the protein, suffer from a combined immunodeficiency characterized by recurrent bacterial and fungal infections and severe T cell lymphopenia. Patient neutrophils have elevated F-actin and superoxide production yet fail to control growth of S. aureus , and the mechanism underlying this killing defect is unknown. Here we re...

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Literature Corpus work: 9720d316-1709-523d-8b31-963b779be491
DOI: 10.64898/2026.05.12.723629

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