Article

Disordered peptides impair neutrophil bacterial clearance and enhance tissue damage in septic patients

2020-07-31

Abstract excerpt

Neutrophilic granulocytes are required for antimicrobial defense, but they can also be harmful to the host organism. The current study demonstrates that disordered peptides in the 3-12 kDa size range in the plasma of septic patients alter effector functions of neutrophils from healthy donors. Those peptides stimulated exocytosis, increased extracellular release of reactive oxygen species (ROS), decreased ROS produ...

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Literature Corpus work: c359b201-2ede-559e-af21-6b74a23957bd
DOI: 10.1101/2020.07.31.227017

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