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Article

Generation of a conditional CREB Ser133Ala knockin mouse.

Genesis (New York, N.Y. : 2000) - 1 Oct 2009

Wingate Andrew D, Martin Kirsty J, Hunter Chris, Carr Julia M, Clacher Carol, Arthur J Simon C

Abstract excerpt

Phosphorylation of Ser133 in the transcription factor CREB is an important mechanism for regulating its transcriptional activity, however recent work has suggested significant roles for other regulatory inputs into CREB. To allow study of this in vivo, we have generated a Ser133 to alanine knockin mutation in the mouse CREB locus. As CREB knockout is perinatal lethal, a minigene strategy was used to allow...

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PMID: 19621437
DOI: 10.1002/dvg.20548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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