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Article

Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock.

Neuron - 11 Apr 2002

Gau Daniel, Lemberger Thomas, von Gall Charlotte, Kretz Oliver, Le Minh Nguyet, Gass Peter, Schmid Wolfgang, Schibler Ueli, Korf Horst W, Schütz Günther

Abstract excerpt

Biological rhythms are driven in mammals by a central circadian clock located in the suprachiasmatic nucleus (SCN). Light-induced phase shifting of this clock is correlated with phosphorylation of CREB at Ser133 in the SCN. Here, we characterize phosphorylation of CREB at Ser142 and describe its contribution to the entrainment of the clock. In the SCN, light and glutamate strongly induce CREB Ser142...

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Source

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PMID: 11970866
DOI: 10.1016/s0896-6273(02)00656-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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