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Article

Generation of a conditional allele of the CBP gene in mouse.

Genesis (New York, N.Y. : 2000) - 1 Oct 2004

Zhang Zuwen, Hofmann Clementine, Casanova Emilio, Schütz Günther, Lutz Beat

Abstract excerpt

CREB-binding protein (CBP) is an important transcriptional cofactor for various intracellular signaling pathways, including Ca(2+)- and cAMP-mediated gene activation. The loss of one CBP allele causes the human Rubinstein-Taybi syndrome, which is characterized by mental retardation and other severe developmental defects. Deletion of both CBP alleles in the mouse leads to early embryonic lethality. To address the...

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PMID: 15452871
DOI: 10.1002/gene.20068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of a conditional allele of the CBP gene in mouse.PMID 15452871Read ↗

Functional analysis of the mouse CBP gene in the adult central nervous systemSemantic proximity Read ↗

Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism.Semantic proximity Read ↗

Introduction of a de novo Creb-binding protein gene mutation in sperm to produce a Rubinstein-Taybi syndrome model using inbred C57BL/6 mice.Semantic proximity Read ↗

Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development.Semantic proximity Read ↗

Syndromic features and mild cognitive impairment in mice with genetic reduction on p300 activity: Differential contribution of p300 and CBP to Rubinstein-Taybi syndrome etiology.Semantic proximity Read ↗

Rubinstein-Taybi syndrome: molecular findings and therapeutic approaches to improve cognitive dysfunction.Semantic proximity Read ↗

Disruption of CREB function in brain leads to neurodegeneration.Semantic proximity Read ↗

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease.Semantic proximity Read ↗

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Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells.Semantic proximity Read ↗

Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome.Semantic proximity Read ↗

Rubinstein-Taybi Syndrome and Epigenetic Alterations.Semantic proximity Read ↗

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