Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.

Abstract excerpt

Hormonally induced increases in cyclic AMP levels induce phosphorylation of the transcription factor CREB at a serine residue at position 133 by protein kinase A (ref. 1), enhancing its ability to activate transcription without affecting its intracellular location or DNA-binding activity. This effect is dependent on a 60-amino-acid region of CREB that contains Ser133 and is termed the kinase-inducible domain...

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