Article
Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.
Nature - 26 Aug 1993
Brindle P, Linke S, Montminy M
Abstract excerpt
Hormonally induced increases in cyclic AMP levels induce phosphorylation of the transcription factor CREB at a serine residue at position 133 by protein kinase A (ref. 1), enhancing its ability to activate transcription without affecting its intracellular location or DNA-binding activity. This effect is dependent on a 60-amino-acid region of CREB that contains Ser133 and is termed the kinase-inducible domain...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cyclic AMP Response Element Modulator
- Cyclic AMP Response Element-Binding Protein
- DNA
- DNA-Binding Proteins
- Fungal Proteins
- Glutamine
- Mice