Article
Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 May 2004
Arthur J Simon C, Fong Amy L, Dwyer Jami M, Davare Monika, Reese Ed, Obrietan Karl, Impey Soren
Abstract excerpt
Activation of the transcription factor cAMP response element-binding protein (CREB) by neurotrophins is believed to regulate the survival, differentiation, and maturation of neurons in the CNS and PNS. Although phosphorylation of Ser133 is critical for the expression of CREB-regulated genes, the identity of neurotrophin-regulated Ser133 kinases has remained controversial. We show here that neurotrophin-induced...
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