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Article

Disruption of CREB function in brain leads to neurodegeneration.

Nature genetics - 1 May 2002

Mantamadiotis Theo, Lemberger Thomas, Bleckmann Susanne C, Kern Heidrun, Kretz Oliver, Martin Villalba Ana, Tronche François, Kellendonk Christoph, Gau Daniel, Kapfhammer Josef, Otto Christiane, Schmid Wolfgang, Schütz Günther

Abstract excerpt

Control of cellular survival and proliferation is dependent on extracellular signals and is a prerequisite for ordered tissue development and maintenance. Activation of the cAMP responsive element binding protein (CREB) by phosphorylation has been implicated in the survival of mammalian cells. To define its roles in the mouse central nervous system, we disrupted Creb1 in brain of developing and adult mice using...

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Identifiers

PMID: 11967539
DOI: 10.1038/ng882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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