Article
Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.
The EMBO journal - 1 Mar 1996
Blendy J A, Kaestner K H, Schmid W, Gass P, Schutz G
Abstract excerpt
To define the role of cAMP signaling in gene control, we have generated mice with a mutation in the cAMP response element binding protein (CREB) gene. Mice carrying this mutation are viable but show an impairment in memory consolidation. In further analysis of these mice, we have found an up-regulation of a CREB isoform that has not been described previously . The new isoform, termed CREB beta, has nearly the...
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