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Article

The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2007

Huggins Gordon S, Lepore John J, Greytak Sarah, Patten Richard, McNamee Rachel, Aronovitz Mark, Wang Paul J, Reed Guy L

Abstract excerpt

Signaling through cAMP plays an important role in heart failure. Phosphorylation of cAMP response element binding protein (CREB) at serine-133 regulates gene expression in the heart. We examined the functional significance of CREB-S133 phosphorylation by comparing transgenic models in which a phosphorylation resistant CREB-S133A mutant containing either an intact or a mutated leucine zipper domain (CREB-S133A-LZ)...

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Identifiers

PMID: 17616745
DOI: 10.1152/ajpheart.00516.2007
PMCID: PMC3911886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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