Article
Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo.
Molecular and cellular biology - 1 Jun 2000
Du K, Asahara H, Jhala U S, Wagner B L, Montminy M
Abstract excerpt
The cyclic AMP (cAMP)-responsive factor CREB promotes cellular gene expression, following its phosphorylation at Ser133, via recruitment of the coactivator paralogs CREB-binding protein (CBP) and p300. CBP and p300, in turn, appear to mediate target gene induction via their association with RNA polymerase II complexes and via intrinsic histone acetyltransferase activities that mobilize promoter-bound nucleosomes....
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