CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.

doi:10.1042/BJ20131115

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Article

CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling.

The Biochemical journal - 15 Mar 2014

Naqvi Shaista, Martin Kirsty J, Arthur J Simon C

Abstract excerpt

CREB (cAMP-response-element-binding protein) is an important transcription factor for the activation of a number of immediate early genes. CREB is phosphorylated on Ser133 by PKA (protein kinase A), promoting the recruitment of the co-activator proteins CBP (CREB-binding protein) and p300; this has been proposed to increase the transcription of CREB-dependent genes. CREB is also phosphorylated on Ser133 by MSK1/2...

Topics

Animals
Cyclic AMP
Cyclic AMP Response Element-Binding Protein
Cyclic AMP-Dependent Protein Kinases
Embryo, Mammalian
Fibroblasts
Gene Knock-In Techniques
Genes, Immediate-Early
MAP Kinase Signaling System
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Mutation

Phosphorylation

Ribosomal Protein S6 Kinases, 90-kDa

Serine

Signal Transduction

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 24438093
DOI: 10.1042/BJ20131115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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