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Article

CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain.

Molecular pain - 26 Apr 2006

Ao Hushan, Ko Shanelle W, Zhuo Min

Abstract excerpt

Cyclic AMP-responsive element binding protein (CREB) activity is known to contribute to important neuronal functions, such as synaptic plasticity, learning and memory. Using a microelectroporation technique to overexpress dominant negative mutant CREB (mCREB) in the adult mouse brain, we found that overexpression of mCREB in the forebrain cortex induced neuronal degeneration. Our findings suggest that...

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Identifiers

PMID: 16640787
DOI: 10.1186/1744-8069-2-15
PMCID: PMC1459854

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