Article
Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival.
BMC neuroscience - 18 May 2012
Tan Yan-Wei, Zhang Sheng-Jia, Hoffmann Tina, Bading Hilmar
Abstract excerpt
BACKGROUND: CREB (cAMP-response element binding protein) is the prototypical signal-regulated transcription factor. In neurons, it is the target of the synaptic activity-induced nuclear calcium-calcium/calmodulin dependent protein kinase (CaMK) IV signaling pathway that controls the expression of genes important for acquired neuroprotection as well as other long-lasting adaptive processes in the nervous system....
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