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Article

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.

PLoS biology - 1 Jul 2009

Kalmar Tibor, Lim Chea, Hayward Penelope, Muñoz-Descalzo Silvia, Nichols Jennifer, Garcia-Ojalvo Jordi, Martinez Arias Alfonso

Abstract excerpt

There is evidence that pluripotency of mouse embryonic stem (ES) cells is associated with the activity of a network of transcription factors with Sox2, Oct4, and Nanog at the core. Using fluorescent reporters for the expression of Nanog, we observed that a population of ES cells is best described by a dynamic distribution of Nanog expression characterized by two peaks defined by high (HN) and low (LN) Nanog...

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Source

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Identifiers

PMID: 19582141
DOI: 10.1371/journal.pbio.1000149
PMCID: PMC2700273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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