Article
Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.
Cell reports - 21 Jun 2016
Acampora Dario, Omodei Daniela, Petrosino Giuseppe, Garofalo Arcomaria, Savarese Marco, Nigro Vincenzo, Di Giovannantonio Luca Giovanni, Mercadante Vincenzo, Simeone Antonio
Abstract excerpt
Mouse embryonic stem cells (ESCs) and the inner cell mass (ICM)-derived epiblast exhibit naive pluripotency. ESC-derived epiblast stem cells (EpiSCs) and the postimplantation epiblast exhibit primed pluripotency. Although core pluripotency factors are well-characterized, additional regulators, including Otx2, recently have been shown to function during the transition from naive to primed pluripotency. Here we...
Topics
- Animals
- Binding Sites
- Blastocyst
- Cell Compartmentation
- Cell Differentiation
- Cell Lineage
- Cell Proliferation
- Chimera
- Embryonic Development
- Embryonic Stem Cells