Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A model-based analysis of culture-dependent phenotypes of mESCs.

PloS one - 1 Jan 2014

Herberg Maria, Kalkan Tüzer, Glauche Ingmar, Smith Austin, Roeder Ingo

Abstract excerpt

Mouse embryonic stem cells (mESCs) can be maintained in a proliferative and undifferentiated state over many passages (self-renewal) while retaining the potential to give rise to every cell type of the organism (pluripotency). Autocrine FGF4/Erk signalling has been identified as a major stimulus for fate decisions and lineage commitment in these cells. Recent findings on serum-free culture conditions with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Computer Simulation
Share to Culture Media, Serum-Free

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryonic Stem Cells

Share to Homeodomain Proteins

Share to Leukemia Inhibitory Factor

Share to Nanog Homeobox Protein

Share to Protein Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 24643025
DOI: 10.1371/journal.pone.0092496
PMCID: PMC3958526

Genes

FGF4
LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A model-based analysis of culture-dependent phenotypes of mESCs.PMID 24643025Read ↗

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.Semantic proximity Read ↗

TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium.Semantic proximity Read ↗

Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.Semantic proximity Read ↗

Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity.Semantic proximity Read ↗

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Semantic proximity Read ↗

Perturb-seq reveals distinct responses to pluripotency regulator dosages underlying the control of self-renewal and differentiationSemantic proximity Read ↗

Defining stemness of human embryonic stem cells : a systems biology approachSemantic proximity Read ↗

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSC Reprogramming FactorsSemantic proximity Read ↗

Control of ground-state pluripotency by allelic regulation of Nanog.Semantic proximity Read ↗

The Regulation of Self-Renewal in Human Embryonic Stem CellsSemantic proximity Read ↗

Extracellular signalling and stem cell self-renewalSemantic proximity Read ↗

A multiscale model of epigenetic heterogeneity reveals the kinetic routes of pathological cell fate reprogrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.