Article
Switching on pluripotency: a perspective on the biological requirement of Nanog.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Aug 2011
Theunissen Thorold W, Silva José C R
Abstract excerpt
Pluripotency is a transient cellular state during early development which can be recreated in vitro by direct reprogramming. The molecular mechanisms driving entry into and exit from the pluripotent state are the subject of intense research interest. Here, we review the role of the homeodomain-containing transcription factor Nanog in mammalian embryology and induced pluripotency. Nanog was originally thought to...
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