Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.

Scientific reports - 20 Nov 2014

Ochiai Hiroshi, Sugawara Takeshi, Sakuma Tetsushi, Yamamoto Takashi

Abstract excerpt

Mouse embryonic stem cells (mESCs) are self-renewing and capable of differentiating into any of the three germ layers. An interesting feature of mESCs is the presence of cell-to-cell heterogeneity in gene expression that may be responsible for cell fate decisions. Nanog, a key transcription factor for pluripotency, displays heterogeneous expression in mESCs, via mechanisms that are not fully understood. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Embryonic Stem Cells
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Mice, Transgenic

Share to Nanog Homeobox Protein

Share to Primary Cell Culture

Share to Stochastic Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 25410303
DOI: 10.1038/srep07125
PMCID: PMC4238020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.PMID 25410303Read ↗

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.Semantic proximity Read ↗

Distinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity.Semantic proximity Read ↗

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Semantic proximity Read ↗

Inferring the kinetics of stochastic gene expression from single-cell RNA-sequencing data.Semantic proximity Read ↗

Using gene expression noise to understand gene regulation.Semantic proximity Read ↗

Allele-specific single-cell RNA sequencing reveals different architectures of intrinsic and extrinsic gene expression noises.Semantic proximity Read ↗

Noise in gene expression: origins, consequences, and control.Semantic proximity Read ↗

Allele-specific detection of single mRNA molecules in situ.Semantic proximity Read ↗

TGF-β-superfamily signaling regulates embryonic stem cell heterogeneity: self-renewal as a dynamic and regulated equilibrium.Semantic proximity Read ↗

Gene expression variations are predictive for stochastic noise.Semantic proximity Read ↗

Control of ground-state pluripotency by allelic regulation of Nanog.Semantic proximity Read ↗

Epigenetic fluctuations underlie gene expression timescales and variability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.