Article
Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease.
Alzheimer disease and associated disorders - 1 Jan 2000
Pihlajamäki Maija, O' Keefe Kelly, Bertram Lars, Tanzi Rudolph E, Dickerson Bradford C, Blacker Deborah, Albert Marilyn S, Sperling Reisa A
Abstract excerpt
The posteromedial cortices and other regions of the "default network" are particularly vulnerable to the pathology of Alzheimer disease (AD). In this study, we performed functional magnetic resonance imaging (fMRI) to investigate whether the presence of apolipoprotein E (APOE) epsilon allele and degree of memory impairment were associated with the dysfunction of these brain regions. Seventy-five elderly subjects...
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