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Article

Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

The American journal of psychiatry - 1 Sept 2006

Wishart Heather A, Saykin Andrew J, Rabin Laura A, Santulli Robert B, Flashman Laura A, Guerin Stephen J, Mamourian Alexander C, Belloni Dorothy R, Rhodes C Harker, McAllister Thomas W

Abstract excerpt

OBJECTIVE: Altered patterns of brain activity during cognitive tasks have been demonstrated using functional magnetic resonance imaging (fMRI) in mild cognitive impairment and Alzheimer's disease. However, there have been few studies of adults at genetic risk for Alzheimer's disease prior to the onset of symptoms. The purpose of this study was to determine whether brain activation patterns associated with working...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16946187
DOI: 10.1176/ajp.2006.163.9.1603

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.PMID 16946187Read ↗

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