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Article

Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.

Brain : a journal of neurology - 1 May 2006

Lind Johanna, Persson Jonas, Ingvar Martin, Larsson Anne, Cruts Marc, Van Broeckhoven Christine, Adolfsson Rolf, Bäckman Lars, Nilsson Lars-Göran, Petersson Karl Magnus, Nyberg Lars

Abstract excerpt

The apolipoprotein E epsilon4 (APOE epsilon4) is the main known genetic risk factor for Alzheimer's disease. Genetic assessments in combination with other diagnostic tools, such as neuroimaging, have the potential to facilitate early diagnosis. In this large-scale functional MRI (fMRI) study, we have contrasted 30 APOE epsilon4 carriers (age range: 49-74 years; 19 females), of which 10 were homozygous for the...

Topics

Aged
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Brain
Brain Mapping
Carrier State
Early Diagnosis
Female
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Hippocampus

Humans

Magnetic Resonance Imaging

Male

Memory

Middle Aged

Neuropsychological Tests

Source

Identifiers

PMID: 16537568
DOI: 10.1093/brain/awl054

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16537568-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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