Article
Impaired default network functional connectivity in autosomal dominant Alzheimer disease.
Neurology - 20 Aug 2013
Chhatwal Jasmeer P, Schultz Aaron P, Johnson Keith, Benzinger Tammie L S, Jack Clifford, Ances Beau M, Sullivan Caroline A, Salloway Stephen P, Ringman John M, Koeppe Robert A, Marcus Daniel S, Thompson Paul, Saykin Andrew J, Correia Stephen, Schofield Peter R, Rowe Christopher C, Fox Nick C, Brickman Adam M, Mayeux Richard, McDade Eric, Bateman Randall, Fagan Anne M, Goate Allison M, Xiong Chengjie, Buckles Virginia D, Morris John C, Sperling Reisa A
Abstract excerpt
OBJECTIVE: To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. METHODS: Eighty-three mutation carriers and 37 asymptomatic noncarriers from the same families...
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