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Article

Progressive accumulation of epigenetic heterogeneity during human ES cell culture.

Epigenetics - 1 Jul 2009

Tanasijevic Borko, Dai Bo, Ezashi Toshihiko, Livingston Kimberly, Roberts R Michael, Rasmussen Theodore P

Abstract excerpt

Human embryonic stem cells (hESCs) can be maintained in culture over a large number of passages while maintaining apparently normal colony morphology. However, recent reports describe variability in epigenetic states in comparisons among different human ES cell lines. These epigenetic differences include changes in CpG methylation, expression of imprinted genes, and the status of X chromosome inactivation (XCI)....

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Identifiers

PMID: 19571681
DOI: 10.4161/epi.4.5.9275
PMCID: PMC9037609

Genes

BMP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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