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Article

Epigenetic regulation of X-inactivation in human embryonic stem cells.

Epigenetics - 1 Jan 2009

Dvash Tamar, Fan Guoping

Abstract excerpt

X chromosome inactivation (XCI) allows dosage compensation of the expression from sex chromosome in mammalian female cells. Although this mechanism is extensively studied in the mouse model organism, the corresponding mechanism during human development is largely unknown. The generation of human embryonic stem cells (hESCs) provides an invaluable tool to address early embryogenesis in humans. Even though hESCs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19106643
DOI: 10.4161/epi.4.1.7438

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