Article
Genomic alterations in cultured human embryonic stem cells.
Nature genetics - 1 Oct 2005
Maitra Anirban, Arking Dan E, Shivapurkar Narayan, Ikeda Morna, Stastny Victor, Kassauei Keyaunoosh, Sui Guoping, Cutler David J, Liu Ying, Brimble Sandii N, Noaksson Karin, Hyllner Johan, Schulz Thomas C, Zeng Xianmin, Freed William J, Crook Jeremy, Abraham Suman, Colman Alan, Sartipy Peter, Matsui Sei-Ichi, Carpenter Melissa, Gazdar Adi F, Rao Mahendra, Chakravarti Aravinda
Abstract excerpt
Cultured human embryonic stem cell (hESC) lines are an invaluable resource because they provide a uniform and stable genetic system for functional analyses and therapeutic applications. Nevertheless, these dividing cells, like other cells, probably undergo spontaneous mutation at a rate of 10(-9) per nucleotide. Because each mutant has only a few progeny, the overall biological properties of the cell culture are...
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