Article
Evaluating the genomic and sequence integrity of human ES cell lines; comparison to normal genomes.
Stem cell research - 1 Mar 2012
Funk Walter D, Labat Ivan, Sampathkumar Janani, Gourraud Pierre-Antoine, Oksenberg Jorge R, Rosler Elen, Steiger Daniel, Sheibani Nadia, Caillier Stacy, Stache-Crain Birgit, Johnson Julie A, Meisner Lorraine, Lacher Markus D, Chapman Karen B, Park Myung Jin, Shin Kyoung-Jin, Drmanac Rade, West Michael D
Abstract excerpt
Copy number variation (CNV) is a common chromosomal alteration that can occur during in vitro cultivation of human cells and can be accompanied by the accumulation of mutations in coding region sequences. We describe here a systematic application of current molecular technologies to provide a detailed understanding of genomic and sequence profiles of human embryonic stem cell (hESC) lines that were derived under...
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