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Article

Epigenetic status of human embryonic stem cells.

Nature genetics - 1 Jun 2005

Rugg-Gunn Peter J, Ferguson-Smith Anne C, Pedersen Roger A

Abstract excerpt

We examined the allele-specific expression of six imprinted genes and the methylation profiles of three imprinting control regions to assess the epigenetic status of human embryonic stem cells. We identified generally monoallelic gene expression and normal methylation patterns. During prolonged passage, one cell line became biallelic with respect to H19, but without loss of the gametic methylation imprint. These...

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Share to DNA Methylation
Share to Embryo, Mammalian
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genomic Imprinting

Share to RNA, Long Noncoding

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Identifiers

PMID: 15864307
DOI: 10.1038/ng1556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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