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Article

Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines.

Genome research - 1 Dec 2007

Kim Kee-Pyo, Thurston Alexandra, Mummery Christine, Ward-van Oostwaard Dorien, Priddle Helen, Allegrucci Cinzia, Denning Chris, Young Lorraine

Abstract excerpt

Disregulation of imprinted genes can be associated with tumorigenesis and altered cell differentiation capacity and so could provide adverse outcomes for stem cell applications. Although the maintenance of mouse and primate embryonic stem cells in a pluripotent state has been reported to disrupt the monoallelic expression of several imprinted genes, available data have suggested relatively higher imprint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17989250
DOI: 10.1101/gr.6609207
PMCID: PMC2099582

Genes

MEST
PEG10
IGF2
KCNQ1
MAGEL2
NDN
PEG3
PHLDA2
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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