Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Measuring gene mutation in vivo.

Progress in clinical and biological research - 1 Jan 1991

Heddle J A, Khan M A, Urlando C, Pagura M E

Abstract excerpt

Both chromosomal aberrations and intragenic mutations are important in the activation of oncogenes and inactivation of antioncogenes. It is now possible to measure both types of mutational events in vivo in a single cell type. The results obtained in both Chinese hamsters and rats are surprising: mutations can be induced in the absence of detectable chromosomal aberrations by some agents and vice versa by others....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Cricetinae
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Mutagenicity Tests

Share to Mutagens

Share to Mutation

Source

Identifiers

PMID: 1956925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Measuring gene mutation in vivo.PMID 1956925Read ↗

Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells.Semantic proximity Read ↗

Somatic cell mutations in cancer epidemiology.Semantic proximity Read ↗

Detection of specific genetic alterations in cancer cells.Semantic proximity Read ↗

The IWGT in vitro Mammalian Cell Gene Mutation (MCGM) assays working group-Introductory remarks & consensus statements.Semantic proximity Read ↗

The potential use of mutation spectra in cancer related genes in genetic toxicology: a statement of a GUM working group.Semantic proximity Read ↗

Gene mutation assays in mammalian cells.Semantic proximity Read ↗

In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.Semantic proximity Read ↗

Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats.Semantic proximity Read ↗

Spontaneous and ethylnitrosourea-induced mutation fixation and molecular spectra at the lacI transgene in the Big Blue rat-2 embryo cell line.Semantic proximity Read ↗

Analysis of in vivo mutation data can inform cancer risk assessment.Semantic proximity Read ↗

Implications for genetic toxicology of the chromosomal breakage syndromes.Semantic proximity Read ↗

Multiple-endpoint mutagenesis with Chinese hamster ovary (CHO) cells: evaluation with eight carcinogenic and non-carcinogenic compounds.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.