Article
Measuring gene mutation in vivo.
Progress in clinical and biological research - 1 Jan 1991
Heddle J A, Khan M A, Urlando C, Pagura M E
Abstract excerpt
Both chromosomal aberrations and intragenic mutations are important in the activation of oncogenes and inactivation of antioncogenes. It is now possible to measure both types of mutational events in vivo in a single cell type. The results obtained in both Chinese hamsters and rats are surprising:...
Topics
- Animals
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Drug Resistance
- Female
- Male
- Micronuclei, Chromosome-Defective
- Mutagenicity Tests
- Mutagens
- Mutation
- Rats
- Thioguanine