In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.

doi:10.1016/0027-5107(92)90131-k

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Article

In vitro mammalian mutagenesis as a model for genetic lesions in human cancer.

Mutation research - 16 Nov 1992

Hozier J, Applegate M, Moore M M

Abstract excerpt

Recently in vitro assays of mutagenesis have been criticized as being poorly predictive of long-term in vivo rodent assays of carcinogenicity. Questions have also been raised concerning the relevance of rodent assays to human risk. In vitro assays using mammalian cells can detect most types of ge...

Topics

Animals
Carcinogenicity Tests
Genes
Genotype
Humans
Mammals
Mice
Models, Genetic
Mutagenicity Tests
Phenotype
Thymidine Kinase

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