Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells.

doi:10.1093/mutage/5.2.179

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Article

Concurrent detection of gene mutations and chromosomal aberrations induced in vivo in somatic cells.

Mutagenesis - 1 Mar 1990

Heddle J A, Bouch A, Khan M A, Gingerich J D

Abstract excerpt

A simple direct assay for gene mutations in vivo is the missing assay in genetic toxicology. Here we report that both gene mutations and chromosomal aberrations induced in vivo can be reliably detected and quantified in a single cell type. Lung cells were isolated and cultured from Chinese hamste...

Topics

Animals
Chromosome Aberrations
Chromosomes
Cricetinae
Cytochalasin B
Micronucleus Tests
Mutagens
Mutation
Organ Specificity

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