Analysis of in vivo mutation data can inform cancer risk assessment.

doi:10.1016/j.yrtph.2008.01.015

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Article

Analysis of in vivo mutation data can inform cancer risk assessment.

Regulatory toxicology and pharmacology : RTP - 1 Jul 2008

Moore Martha M, Heflich Robert H, Haber Lynne T, Allen Bruce C, Shipp Annette M, Kodell Ralph L

Abstract excerpt

Under the new U.S. Environmental Protection Agency (EPA) Cancer Risk Assessment Guidelines [U.S. EPA, 2005. Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001B, March 2005], the quantitative model chosen for cancer risk assessment is based on the mode-of-action (MOA) of the chemical under consideration. In particular, the risk assessment model depends on whether or not the chemical causes tumors through...

Topics

Animals
Carcinogens
DNA
Dose-Response Relationship, Drug
Guidelines as Topic
Humans
Mutagens
Mutation
Neoplasms
Risk Assessment
United States
United States Environmental Protection Agency

Source

Open in PubMed

Identifiers

PMID: 18321622
DOI: 10.1016/j.yrtph.2008.01.015

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