Article
Detection of specific genetic alterations in cancer cells.
Seminars in oncology - 1 Feb 1996
Huebner K, Ohta M, Lubinski J, Berd D, Magüire H C
Abstract excerpt
The genetic changes found in human neoplasms suggest that hematopoietic tumors develop mainly from inappropriate expression (usually overexpression) of a growth promoting gene (oncogene). In contrast, the progression to malignancy of carcinomas occurs mainly through loss of tumor suppressor genes...
Topics
- Base Sequence
- Gene Deletion
- Genes, Suppressor
- Humans
- Kidney Neoplasms
- Melanoma
- Molecular Sequence Data
- Mutation
- Neoplasms
- Oncogenes