Implications for genetic toxicology of the chromosomal breakage syndromes.

doi:10.1016/0027-5107(91)90018-j

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Article

Implications for genetic toxicology of the chromosomal breakage syndromes.

Mutation research - 1 Apr 1991

Heddle J A

Abstract excerpt

The activation of oncogenes and our knowledge of the chromosome breakage syndromes show that both intragenic mutations and chromosomal aberrations are important in carcinogenesis. Each suggests that an agent could produce genetic changes in a tissue without producing cancer there, if the types of...

Topics

Carcinogenicity Tests
Chromosome Aberrations
DNA Damage
False Positive Reactions
Gene Expression Regulation
Humans
Mutagenicity Tests
Mutation
Neoplasms
Sex Factors
Syndrome

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