Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats.

doi:10.1016/0165-7992(91)90010-2

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Article

Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats.

Mutation research - 1 Aug 1991

Khan M A, Heddle J A

Abstract excerpt

Rats can be used to detect both somatic gene mutations and chromosomal aberrations induced in vivo. The technique adapted from Chinese hamsters for the isolation and analysis of lung fibroblasts confirm the surprising results obtained in hamsters; namely, methyl methanesulphonate induces many mic...

Topics

Animals
Cells, Cultured
Chromosome Aberrations
Dose-Response Relationship, Drug
Ethylnitrosourea
Fibroblasts
Lung
Male
Methyl Methanesulfonate
Micronucleus Tests
Mutagenicity Tests
Mutation
Rats
Rats, Inbred F344

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