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Article

Chemical induction of somatic gene mutations and chromosomal aberrations in lung fibroblasts of rats.

Mutation research - 1 Aug 1991

Khan M A, Heddle J A

Abstract excerpt

Rats can be used to detect both somatic gene mutations and chromosomal aberrations induced in vivo. The technique adapted from Chinese hamsters for the isolation and analysis of lung fibroblasts confirm the surprising results obtained in hamsters; namely, methyl methanesulphonate induces many micronuclei but no significant increase in gene mutations. In contrast ethylnitrosourea induces both micronuclei and gene...

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PMID: 1861691
DOI: 10.1016/0165-7992(91)90010-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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