Article
Spontaneous and ethylnitrosourea-induced mutation fixation and molecular spectra at the lacI transgene in the Big Blue rat-2 embryo cell line.
Environmental and molecular mutagenesis - 1 Jan 1996
Zimmer D M, Zhang X B, Harbach P R, Mayo J K, Aaron C S
Abstract excerpt
Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures were 100, 200, 400, 600, and 1,000 micrograms E...
Topics
- Animals
- Animals, Genetically Modified
- Bacterial Proteins
- Cell Death
- Cell Division
- Cell Line
- Dose-Response Relationship, Drug
- Embryo, Mammalian
- Escherichia coli Proteins
- Ethylnitrosourea
- Lac Repressors
- Mutagenicity Tests
- Mutagens
- Mutation
- Rats
- Repressor Proteins
- Sequence Analysis, DNA
- Transgenes