Multiple-endpoint mutagenesis with Chinese hamster ovary (CHO) cells: evaluation with eight carcinogenic and non-carcinogenic compounds.

Article

Multiple-endpoint mutagenesis with Chinese hamster ovary (CHO) cells: evaluation with eight carcinogenic and non-carcinogenic compounds.

Molecular toxicology - 1 Jan 2000

Hsie A W, San Sebastian J R, Perdue S W, Schenley R L, Waters M D

Abstract excerpt

Previously, we have shown that Chinese hamster ovary (CHO) cells are useful for quantifying chemical-induced gene mutations. We have defined the conditions of a Multiplex CHO System which permits determination of mutagen-induced chromosome aberration, and sister chromatid exchange (SCE) in additi...

Topics

Animals
Carcinogens
Cell Line
Cell Survival
Chromosome Aberrations
Cricetinae
Mutagenicity Tests
Mutation
Sister Chromatid Exchange
Structure-Activity Relationship

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