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Article

Numb regulates post-endocytic trafficking and degradation of Notch1.

The Journal of biological chemistry - 25 Sept 2009

McGill Melanie A, Dho Sascha E, Weinmaster Gerry, McGlade C Jane

Abstract excerpt

Notch is a transmembrane receptor that controls cell fate decisions during development and tissue homeostasis. Both activation and attenuation of the Notch signal are tightly regulated by endocytosis. The adaptor protein Numb acts as an inhibitor of Notch and is known to function within the intracellular trafficking pathways. However, a role for Numb in regulating Notch trafficking has not been defined. Here we...

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Identifiers

PMID: 19567869
DOI: 10.1074/jbc.M109.014845
PMCID: PMC2785331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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