Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.

Traffic (Copenhagen, Denmark) - 1 Sept 2008

Sorensen Erika B, Conner Sean D

Abstract excerpt

Numb is an endocytic protein that is proposed to influence clathrin-coated pit assembly, although its mode of action and the mechanisms that regulate its activity are unknown. In this study, we show that Numb binds to and is phosphorylated by adaptor-associated kinase 1 (AAK1), a key endocytic kinase. We find that AAK1 redistributes Numb to perinuclear endosomes when overexpressed, while kinase depletion causes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clathrin
Share to Endocytosis
Share to Endosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to HeLa Cells

Share to Immunoprecipitation

Share to Protein Serine-Threonine Kinases

Share to Protein Transport

Source

Identifiers

PMID: 18657069
DOI: 10.1111/j.1600-0854.2008.00790.x

Genes

AAK1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis.PMID 18657069Read ↗

The Multitasker Protein: A Look at the Multiple Capabilities of NUMBSemantic proximity Read ↗

Numb regulates post-endocytic trafficking and degradation of Notch1.Semantic proximity Read ↗

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila.Semantic proximity Read ↗

Regulation of calcium influx and signaling pathway in cancer cells via TRPV6-Numb1 interaction.Semantic proximity Read ↗

Numb Regulates Stability and Localization of the Mitotic Kinase PLK1 and Is Required for Transit through MitosisSemantic proximity Read ↗

Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis.Semantic proximity Read ↗

HEATR5B associates with dynein-dynactin and selectively promotes motility of AP1-bound endosomal membranesSemantic proximity Read ↗

Two novel human NUMB isoforms provide a potential link between development and cancerSemantic proximity Read ↗

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics.Semantic proximity Read ↗

Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif.Semantic proximity Read ↗

The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.Semantic proximity Read ↗

Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.