Article

The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels

2025-03-03

Abstract excerpt

NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss-of-function (LOF), mediated by various molecular mechanisms, is a frequent and causal event. Herein, we establish that loss of NUMB protein, resulting from protein hyper-degradation, is the prevalent mechanism...

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Literature Corpus work: 29c039bd-4584-577a-b87c-e844a6dec7de
DOI: 10.1101/2025.02.27.640530

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The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB LevelsDOI 10.1101/2025.02.27.640530Read

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