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Article

Endocytosis by Numb breaks Notch symmetry at cytokinesis.

Nature cell biology - 22 Jan 2012

Couturier Lydie, Vodovar Nicolas, Schweisguth François

Abstract excerpt

Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not...

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Identifiers

PMID: 22267085
DOI: 10.1038/ncb2419

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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