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Article

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila.

Developmental cell - 1 Aug 2002

Berdnik Daniela, Török Tibor, González-Gaitán Marcos, Knoblich Juergen A

Abstract excerpt

During asymmetric cell division in Drosophila sensory organ precursor cells, the Numb protein localizes asymmetrically and segregates into one daughter cell, where it influences cell fate by repressing signal transduction via the Notch receptor. We show here that Numb acts by polarizing the distribution of alpha-Adaptin, a protein involved in receptor-mediated endocytosis. alpha-Adaptin binds to Numb and...

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Source

Identifiers

PMID: 12194853
DOI: 10.1016/s1534-5807(02)00215-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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