Article
Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.
Molecular and cellular biology - 1 Sept 2009
Kalinina Juliya, Byron Sara A, Makarenkova Helen P, Olsen Shaun K, Eliseenkova Anna V, Larochelle William J, Dhanabal Mohanraj, Blais Steven, Ornitz David M, Day Loren A, Neubert Thomas A, Pollock Pamela M, Mohammadi Moosa
Abstract excerpt
Uncontrolled fibroblast growth factor (FGF) signaling can lead to human diseases, necessitating multiple layers of self-regulatory control mechanisms to keep its activity in check. Herein, we demonstrate that FGF9 and FGF20 ligands undergo a reversible homodimerization, occluding their key receptor binding sites. To test the role of dimerization in ligand autoinhibition, we introduced structure-based mutations...
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