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Article

Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization.

Structure (London, England : 1993) - 5 Sept 2017

Liu Yang, Ma Jinghong, Beenken Andrew, Srinivasan Lakshmi, Eliseenkova Anna V, Mohammadi Moosa

Abstract excerpt

The epithelial fibroblast growth factor 9 (FGF9) subfamily specifically binds and activates the mesenchymal "c" splice isoform of FGF receptors 1-3 (FGFR1-3) to regulate organogenesis and tissue homeostasis. The unique N and C termini of FGF9 subfamily ligands mediate a reversible homodimerization that occludes major receptor binding sites within the ligand core region. Here we provide compelling X-ray...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28757146
DOI: 10.1016/j.str.2017.06.016
PMCID: PMC5587394

Genes

FGF9
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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