Article
Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization.
Molecular and cellular biology - 1 Jan 2005
Ibrahimi Omar A, Yeh Brian K, Eliseenkova Anna V, Zhang Fuming, Olsen Shaun K, Igarashi Makoto, Aaronson Stuart A, Linhardt Robert J, Mohammadi Moosa
Abstract excerpt
Two competing models for fibroblast growth factor (FGF) receptor (FGFR) dimerization have recently emerged based on ternary FGF-FGFR-heparin crystal structures. In the symmetric two-end model, heparin promotes dimerization of two FGF-FGFR complexes by stabilizing bivalent interactions of the ligand and receptor through primary and secondary sites and by stabilizing direct receptor-receptor contacts. In the...
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