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Article

Instability restricts signaling of multiple fibroblast growth factors.

Cellular and molecular life sciences : CMLS - 1 Jun 2015

Buchtova Marcela, Chaloupkova Radka, Zakrzewska Malgorzata, Vesela Iva, Cela Petra, Barathova Jana, Gudernova Iva, Zajickova Renata, Trantirek Lukas, Martin Jorge, Kostas Michal, Otlewski Jacek, Damborsky Jiri, Kozubik Alois, Wiedlocha Antoni, Krejci Pavel

Abstract excerpt

Fibroblast growth factors (FGFs) deliver extracellular signals that govern many developmental and regenerative processes, but the mechanisms regulating FGF signaling remain incompletely understood. Here, we explored the relationship between intrinsic stability of FGF proteins and their biological activity for all 18 members of the FGF family. We report that FGF1, FGF3, FGF4, FGF6, FGF8, FGF9, FGF10, FGF16, FGF17,...

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Source

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Identifiers

PMID: 25854632
DOI: 10.1007/s00018-015-1856-8
PMCID: PMC11113989

Genes

FGF1
FGF10
FGF16
FGF17
FGF20
FGF3
FGF4
FGF6
FGF8
FGF18
FGF22
FGF9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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