Article

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination

2018-06-21

Abstract excerpt

Upon ligand engagement, the single-pass transmembrane receptor tyrosine kinases (RTKs) dimerize to transmit qualitatively and quantitatively different intracellular signals that alter the transcriptional landscape and thereby determine the cellular response. The molecular mechanisms underlying these fundamental events are not well understood. Considering recent insights into the structural biology of fibroblast gr...

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Literature Corpus work: f0475349-cd6e-57a6-a0fe-9c52c906438e
DOI: 10.12688/f1000research.14143.1

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